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Abstract #3572

Influence of a severe internal carotid artery stenosis on diffusion and perfusion values in acute stroke patients

Philipp Kaesemann 1 , Gtz Thomalla 2 , Bastian Cheng 2 , Andras Treszl 3 , Jens Fiehler 4 , and Nils Daniel Forkert 5

1 Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2 Department of Neurology, University Medical Center Hamburg-Eppendorf, Germany, 3 Department of Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Germany, 4 Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Germany, 5 Department of Radiology and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada

The effect of a long-lasting internal carotid artery (ICA) stenosis on the diffusion and perfusion situation in patients with an acute ischemic stroke is not well understood. Within this context, it may be hypothesized that an ICA stenosis leads to a more severe hypoperfusion situation. On the other hand, an ICA stenosis may be even beneficial in case of an acute stroke due to a prior development of an improved collateral situation or preconditioning of the brain tissue. The objective of this study was to compare lesion volumes as well as diffusion and perfusion parameters in acute ischemic stroke patients with or without a coexisting ICA stenosis.

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