Abstract #3574
Understanding the interplay different MRI methods have as white matter changes longitudinally in the cuprizone mouse model
Vanessa L Palmer 1 , Sheryl L Herrera 2 , Jonathan D Thiessen 3,4 , Shenghua Zhu 5 , Richard Buist 6 , Xin-Min Li 7 , Marc R Del Bigio 8 , and Melanie Martin 9,10
1
Biomedical Engineering, University of
Manitoba, Winnipeg, Manitoba, Canada,
2
Physics
& Astronomy, University of Mantioba, Winnipeg, Manitoba,
Canada,
3
Imaging Program, Lawson Health
Research Institute, London, Ontario, Canada,
4
Medical
Biophysics, Western University, London, Ontario, Canada,
5
Pharmacology
& Therapeutics, University of Mantioba, Winnipeg,
Manitoba, Canada,
6
Radiology,
University of Mantioba, Winnipeg, Manitoba, Canada,
7
Psychiatry,
University of Alberta, Edmonton, Alberta, Canada,
8
Pathology,
University of Mantioba, Winnipeg, Manitoba, Canada,
9
Physics,
University of Winnipeg, Winnipeg, Manitoba, Canada,
10
Biomedical
Engineering, Physics &Astronomy, Pharmacology
&Therapeutics, Radiology, University of Mantioba,
Winnipeg, Manitoba, Canada
DTI, qMTI, and multicomponent T2 relaxometry might help
quantify changes related to white matter (WM) damage. To
understand the interplay MRI methods have as WM changes
in the corpus callosum and external capsule of the
cuprizone mouse model,
in
vivo
T2w
images and MTI were acquired weekly in control and
cuprizone-fed mice. Weekly DTI, qMTI, T1/T2 relaxometry,
T2w imaging, and EM were used to analyze
ex
vivo
tissue
after each week of cuprizone delivery. The addition of
weekly
ex
vivo
tissue
analysis allows for a more complete understanding of the
correlations between MR metrics and EM measures of
tissue pathology.
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