Abstract #3597
Neuroplasticity for spontaneous functional recovery after neonatal hypoxic ischemic injury
Won Beom Jung 1,2 , Geun Ho Im 1,2 , Sun Young Chae 3 , Yong Hee Han 1,2 , and Jung Hee Lee 1,3
1
Department of Radiology Samsung Medical
Center, Sungkyunkwan University School of Medicine,
Seoul, Korea,
2
Center
for Molecular and Cellular Imaging Samsung Biomedical
Research Institute, Seoul, Korea,
3
Samsung
Advanced Institute of Health Science and Technology
Sungkyunkwan University, Seoul, Korea
In this study, we examined the functional and anatomical
brain changes in perinatal hypoxic ischemic injured rat
brain with BOLD-fMRI, DTI and rs-fMRI. HI injured brains
were observed with the the widespread sensory-motor
related areas on intact forelimb, weakly evoked brain
activation on impaired forelimb, intra-hemispheric track
rewiring and enhanced intra-connectivity in cingulate
cortex areas compared with sham-operated brains. In
addition, impared forelimb show the behavioral
perfomance although not complete. We believe that brain
modulations in HI induced rats are the neuralplasticity
for spontaneous recovery to compensate for functional
loss.
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