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Abstract #3600

MRI Investigation of Cerebrovascular Reactivity and Neurovascular Coupling in Chronic Hypertension

Yunxia Li 1,2 , Shiliang Huang 1 , Qiang Shen 1 , Eric R Muir 1 , and Timothy Q Duong 1

1 Research Imaging Institute, The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 2 Department of Neurology, Tongji Hospital, Tongji University, Shanghai, China

Magnetic resonance imaging (MRI) has been widely used to study neurovascular coupling and evoked responses under normal conditions and in neurological diseases in vivo. Chronic hypertension will change the function of brain. The goal of this study is to use MRI to evaluate the effects of chronic hypertension on BOLD and CBF responses to hypercapnic challenge, and BOLD, CBF responses to forepaw stimulation in the in vivo in spontaneously hypertensive rats. 40 weeks SHR has the compromised cerebravascular response to hypercapnia challenge, which should come from the hypertensive damage to cerebral vascular. The greater fMRI responses to forepaw stimulation are correlated with the higher blood pressure.

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