MRI Investigation of Cerebrovascular Reactivity and Neurovascular Coupling in Chronic Hypertension
Yunxia Li 1,2 , Shiliang Huang 1 , Qiang Shen 1 , Eric R Muir 1 , and Timothy Q Duong 1
Research Imaging Institute, The University
of Texas Health Science Center at San Antonio, San
Antonio, TX, United States,
of Neurology, Tongji Hospital, Tongji University,
Magnetic resonance imaging (MRI) has been widely used to
study neurovascular coupling and evoked responses under
normal conditions and in neurological diseases in vivo.
Chronic hypertension will change the function of brain.
The goal of this study is to use MRI to evaluate the
effects of chronic hypertension on BOLD and CBF
responses to hypercapnic challenge, and BOLD, CBF
responses to forepaw stimulation in the in vivo in
spontaneously hypertensive rats. 40 weeks SHR has the
compromised cerebravascular response to hypercapnia
challenge, which should come from the hypertensive
damage to cerebral vascular. The greater fMRI responses
to forepaw stimulation are correlated with the higher
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