Abstract #3612
The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-defined Normal Tissue, Ischemic Penumbra and Ischemic Core
Zhao Jiang 1 , Lora Talley Watts 1 , Shiliang Huang 1 , Pavel Rodriguez 1 , Qiang Shen 1 , and Timothy Duong 1
1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
TX, United States
Methylene blue (MB) USP, which has energy-enhancing and
antioxidant properties, is currently used to treat
methemoglobinemia and cyanide poisoning in humans. We
recently showed that MB administration reduces infarct
volume and behavioral deficits in rat models of ischemic
stroke and traumatic brain injury. This study reports
the underlying molecular mechanisms of MB
neuroprotection following transient ischemic stroke in
rats.
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