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Abstract #3615

Non-invasive identification of crossed cerebellar diaschisis following cerebral ischemic stroke using combined measures of cerebrovascular reactivity, cerebral blood flow, and Wallerian degeneration

Carlos C. Faraco 1 , Manus J. Donahue 1,2 , Cari L. Buckingham 1 , Fei Ye 3 , Lori C. Jordan 2 , Daniel F. Arteaga 1 , and Megan K. Strother 1

1 Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, TN, United States, 2 Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, 3 Center for Quantitative Sciences, Vanderbilt University School of Medicine, Nashville, TN, United States

Cross cerebellar diaschisis (CCD) is a hypometabolic condition associated with reduced cerebellar blood flow to the hemisphere contralateral to a supratentorial lesion. CCD remains poorly understood partly owing to use of diagnostic modalities not readily available and/or not suitable for longitudinal monitoring, e.g., PET, SPECT, and Gd-MR. The primary aim of this study was to determine whether cerebellar BOLD-weighted cerebrovascular reactivity (CVR) contralateral to supratentorial infarcts correlated with structural and clinical measures of CCD. We demonstrate that BOLD-weighted CVR in the contralateral cerebellar hemisphere correlates with these measures and is a viable, non-invasive alternative to traditional CCD diagnostic imaging modalities.

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