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Abstract #3644

Hepatic Fat Quantification for suspected NAFLD Patients Using 3 Different Methods: HISTO, 3D Multi-Echo GRE DIXON and Invasive Liver Biopsy

Wei Wang 1 , Xiuzhong Yao 1 , Hongmei Yan 2 , Hua Bian 2 , Xiaodong Zhong 3 , Radhouene Neji 4 , Caixia Fu 5 , Hui Liu 6 , Dehe Weng 5 , Ignacio Vallines 6 , and Mengsu Zeng 1

1 Radiology Department, Zhongshan Hospital, Fudan University, Shanghai, Shanghai, China, 2 Endocrinology Department, Zhongshan Hospital, Fudan University, Shanghai, China, 3 MR collaborations, Siemens Healthcare, Atlanta, Georgia, United States, 4 MR collaborations, Siemens Healthcare, Frimley, Camberley, United Kingdom, 5 Application Department, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, Guangdong, China, 6 MR collaborations, Siemens Healthcare, Shanghai, China

Accurate non-invasive detection and quantification of proton density fat fraction (PDFF) as a marker for liver fat in patients with non-alcoholic fatty liver disease (NAFLD) is gaining increasing interest. The aim of this study was to evaluate both rapid single breath-hold, multi-echo, T2 corrected single-voxel spectroscopy( HISTO ), and a recently developed, multi-echo 3D gradient echo acquisitions using a hybrid multi-step fitting approach (Advanced Dixon, AD) with conventional, invasive liver biopsy as a reference for hepatic fat quantification in NAFLD patients.

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