T1 corrected fat quantification using a dual flip angle acquisition and joint fit reconstruction
Xiaoke Wang 1 , Diego Hernando 2 , and Scott B. Reeder 2,3
Biomedical Engineering, University of
Wisconsin, Madison, Wisconsin, United States,
University of Wisconsin, Madison, Wisconsin, United
Medical Physics, University of
Wisconsin, Madison, Wisconsin, United States
The estimation of PDFF by CSE imaging may be biased by
T1 relaxation. T1 related bias can be minimized by using
a small flip angle (SFA) approach. SFA results in
reduced SNR and residual bias. T1 bias can also be
corrected using a dual flip angle method (standard DFA),
which redundantly estimates R2* and B0 twice. In this
study, we propose a joint fitting of T1, B0, R2* and
PDFF based on dual-flip-angle acquisition (joint DFA).
Joint DFA slightly reduced noise in R2* and PDFF
estimates compared with standard DFA as shown by
Cramer-Rao lower bound and Monte Carlo simulation.
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