Meeting Banner
Abstract #3665

Triglyceride content and fatty acid composition in mice: quantification with 7.0T MRI

Benjamin Leporq 1 , Simon Auguste Lambert 1,2 , Francois Cauchy 1,3 , Imane Boucenna 4 , Pierre Colinart 4 , Maxime Ronot 1,5 , Valerie Vilgrain 1,5 , Valerie Paradis 1,6 , and Bernard Edgar Van Beers 1,5

1 Center of research on inflammation, Paris 7 University; INSERM U1044, Paris, France, 2 BHF Centre of Excellence, Division of Imaging Sciences and Biomedical Engineering, Kings College London Kings Health Partners, St. Thomas Hospital, London, United Kingdom, 3 Department of HPB and liver transplantation, Beaujon University hospital Paris Nord, Clichy, France, 4 Matire et systmes complexes, Paris 7 University; CNRS UMR 7057, Paris, France, 5 Department of Radiology, Beaujon University hospital Paris Nord, Clichy, France, 6 Department of Pathology, Beaujon University hospital Paris Nord, Clichy, France

This work report a MRI method able to quantify both fat content and fatty acid composition on preclinical systems at 7.0T. MR acquisition was based on a spoiled multiple gradient echoes sequence with bipolar readout gradient. After phase unwrapping, complex images were rebuilt. By using a model including water and eight fat resonances each expressed according to ndb, nmidb and CL, parametric images such as PDFF, SFA, MUFA and PUFA were reconstructed. Results suggest that it possible to follow diet effects on fat content and fatty acid compositions in mice with this method.

This abstract and the presentation materials are available to members only; a login is required.

Join Here