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Abstract #3690

Fast Aortic Input Function Extraction at High Temporal Resolution for DCE-MRI

Umit Yoruk 1,2 , Manojkumar Saranathan 1 , Tao Zhang 1 , Brian A Hargreaves 1 , and Shreyas S Vasanawala 1

1 Radiology, Stanford University, Stanford, CA, United States, 2 Electrical Engineering, Stanford University, Stanford, CA, United States

Many pharmacokinetic models in DCE-MRI need subject-based aortic input function (AIF). Accurate AIF measurement requires high temporal resolution images, which compromises the image spatial resolution. A recently developed low-rank reconstruction technique allows reconstruction of two sets of images, a high temporal resolution image for quantitative analysis and a high spatial resolution image for clinical evaluation, at a cost of increased reconstruction time. We present a faster method for extracting high temporal resolution AIF from DCE-MRI data and compare it to the low-rank reconstruction. The feasibility of this method was demonstrated on a pediatric subject.

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