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Abstract #3752

Comparison of 3 He MRI and CT image-based ventilation using deformable image registration

Bilal A Tahir 1,2 , Helen Marshall 2 , Matthew Q Hatton 1 , Jim M Wild 2 , and Rob H Ireland 1,2

1 Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom, 2 Academic Unit of Academic Radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Image registration of inspiratory and expiratory lung CT has been proposed to generate surrogates of ventilation. However, validation against established ventilation modalities is required prior to clinical implementation. Here, we present a method using deformable image registration, via same-breath 1H MRI, to enable ROI correlation analysis of ventilation calculated by dual breath-hold CT with hyperpolarized 3He MRI, which is demonstrated in 3 patients with moderate-to-severe asthma.

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