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Abstract #3799

Evaluation of the Errors in the Measured Dynamic Contrast Enhancement with TWIST View Sharing Using a Novel Simulation Strategy

Yuan Le 1 , Marcel Dominik Nickel 2 , Randall Kroeker 3 , Christian Geppert 2 , Bruce Spottiswoode 3 , and Chen Lin 1

1 Radiology and Imaging Science, Indiana University School of Medicine, Indianapolis, IN, United States, 2 Siemens Healthcare, Erlangen, Bavaria, Germany, 3 Siemens Medical Solutions, NC, United States

In order to investigate the representation of complex tumors when using modern, view sharing MRI sequences such as TWIST, dynamic contrast-enhanced TWIST raw data were generated from static background and a fractal tumor phantom raw data scaled with an enhancement model. Our results show that, for typical spatial resolution in clinical breast DCE-MRI, TWIST parameters of pA=20%-25% and pB=33% provided an enhancement measurement with lowest RMS error. The measured shape irregularity of the tumor changed in a less predictable way, however, which should be taken into consideration in the texture analysis of the images.

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