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Abstract #3811

Biomarkers of Aggressive Breast Cancer Revealed by Combining Magnetic Resonance Spectroscopic Imaging and Mass Spectrometric Imaging

Lu Jiang 1 , Kamila Chughtai 2 , Tiffany Greenwood 1 , Zaver M. Bhujwalla 1 , Venu Raman 1 , Gert Eijkel 2 , Ron Heeren 2 , and Kristine Glunde 1

1 Department of Radiology, Johns Hopkins University School of Medic, BALTIMORE, MD, United States, 2 FOM-Institute AMOLF, Amsterdam, Netherlands

The total choline (tCho) signal in magnetic resonance spectroscopic imaging (MRSI) of tumors is a potential biomarker of breast cancer aggressiveness and can be visualized in vivo by H1 MRSI tCho maps. Mass spectrometry imaging (MSI) of histologic tumor sections is able to detect thousands of biomolecules, including tryptic peptides from on-tissue digested proteins, from the tissue surface. We have investigated differentially regulated proteins in high- versus low-tCho regions in a human breast cancer model by combining in vivo MRSI with ex vivo MSI, which identified specific protein species that are spatially correlated with tCho.

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