Monitoring gas-induced haemodynamic changes in the breast with BOLD contrast
Tess Catherwood 1 , Andrew Patterson 1 , Martin Graves 1 , Reem Bedair 1 , Roie Manavaki 1 , Mary McLean 2 , John Griffiths 2 , and Fiona Gilbert 1
Radiology, Cambridge University Hospitals
NHS Foundation Trust, Cambridge, Cambridgeshire, United
Research UK Cambridge Institute, Cambridge,
Cambridgeshire, United Kingdom
BOLD contrast MRI with hyperoxic gas challenge may
provide a biomarker of breast tumour oxygenation and
vascular function, with the potential to predict
treatment response. This study measured the strength of
BOLD response to carbogen-light (2% CO
interleaved with medical air and oxygen, compared to an
all-air control, in six healthy volunteers.
Carbogen-light was effective in inducing a measurable
BOLD effect with respect to background physiological
noise, without the respiratory discomfort often reported
with 5% CO
In general carbogen-light versus oxygen induced a
larger response, consistent with the opposing
vasomodulatory effects of these two stimuli.
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