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Abstract #3851

Saturation duration and power optimization for APT MRI of prostate cancer

Harsh K Agarwal 1,2 , Jochen Keupp 3 , Marcelino Bernardo 2 , Baris Turkbey 2 , and Peter L Choyke 2

1 Philips Research NA, Briarcliff Manor, New York, United States, 2 National Institutes of Health, Bethesda, MD, United States, 3 Philips Research Laboratories, Hamburg, Germany

Amide proton transfer (APT) MRI has been shown to localize and stage prostate. However there are multiple parameters such as saturation power and saturation duration that affect the APT MRI contrast. In this abstract we have shown that MTR asymmetry increased with the decrease in the pulse duration. Also the peak of MTR asymmetry shifted with the change in saturation power. However spurious MTR was observed over prostate especially in peripheral zone which could be due to the incoherent motion such as rectal spasm.

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