Abstract #3856
Constrained multi-agent tracer-kinetic modeling to assess tumor vascular changes induced by DMXAA treatment
Igor Jacobs 1 , Stefanie Hectors 1 , Gustav Strijkers 1,2 , Klaas Nicolay 1 , and Matthias Schabel 3,4
1
Biomedical NMR, Department of Biomedical
Engineering, Eindhoven University of Technology,
Eindhoven, Netherlands,
2
Biomedical
Engineering and Physics, Academic Medical Center,
University of Amsterdam, Amsterdam, Netherlands,
3
Advanced
Imaging Research Center, Oregon Health and Science
University, Portland, Oregon, United States,
4
Utah
Center for Advanced Imaging Research, University of
Utah, Salt Lake City, Utah, United States
Accurate evaluation of antivascular tumor therapies
requires detailed analysis of vascular alterations. We
have recently proposed a novel multi-agent
tracer-kinetic modeling approach for DCE-MRI, which
allows simultaneous and self-consistent assessment of
blood flow and permeability within one imaging session.
In the present study, we have applied this approach to
evaluate DMXAA treatment. An early increase in
extraction fraction of the dendrimer-based contrast
agents and reduced blood flow were simultaneously
observed, thereby identifying increased permeability as
the main mechanism of DMXAA-induced vascular shutdown,
in agreement with literature. This demonstrates the
potential of the multi-agent approach to assess
therapy-induced vascular changes.
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