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Abstract #3860

Metabolic Imaging of Early Tumor Therapy

Charles S. Springer 1,2 , Xin Li 3 , Mohan L. Jayatilake 4 , Martin M. Pike 2,3 , William D. Rooney 3 , Rosalie C. Sears 2,5 , and Wei Huang 2,3

1 Advanced Imaging Research Center, Oregon Health & Science University, Portland, Or, United States, 2 Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States, 3 Advanced Imaging Research Center, Oregon Health & Science University, Portland, Oregon, United States, 4 Radiography and Radiotherapy, University of Peradeniya, Peradeniya, Peradeniya, Sri Lanka, 5 Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, United States

Normally, DCE-MRI estimates vascular parameters, K trans and v p . However, shutter-speed analysis allows determination of cellular, metabolic parameters, k io and v i . The k io quantity tracks cell membrane Na + ,K + -ATPase activity. Exemplified with human and murine breast cancers, we show that these enable the discrimination of cytotoxic and targeted therapies in their early actions.

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