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Abstract #3881

Multi-parametric Longitudinal Study for the Evaluation of Tumor Heterogeneity in Breast Cancer Patients Using Simultaneous MRSI & DWI Techniques

Naranamangalam R Jagannathan 1 , Khushbu Agarwal 1 , Uma Sharma 1 , Smriti Hari 2 , Vurthaluru Seenu 3 , and Rajinder Parshad 3

1 Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, Delhi, India, 2 Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, Delhi, India, 3 Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, Delhi, India

ChoSNR and ADC were measured from same voxels in different breast tumor regions (solid tumor, necrosis and margin) prior to and after III NACT in 11 LABC patients (6 clinical responders and 5 non-responders). In responders, increased ChoSNR with decreased ADC of solid tumor was observed after therapy. ChoSNR decreased significantly with no ADC change at tumor margin. At necrosis no change in ChoSNR or ADC was seen. In non-responders ChoSNR and ADC did not change in tumor regions. Positive Pearson correlation between ChoSNR and ADC change signifies combined utility of both techniques simultaneously in therapeutic management of breast cancer.

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