Abstract #3887
Clinical Utility of Sequential DWI in Studying Tumor Margins as an aid to Breast Conservation Surgery
Naranamangalam R Jagannathan 1 , Khushbu Agarwal 1 , Rani G Sah 1 , Uma Sharma 1 , Smriti Hari 2 , Vurthaluru Seenu 3 , and Rajinder Parshad 3
1
Department of NMR & MRI Facility, All India
Institute of Medical Sciences, New Delhi, Delhi, India,
2
Department
of Radiodiagnosis, All India Institute of Medical
Sciences, New Delhi, Delhi, India,
3
Department
of Surgical Disciplines, All India Institute of Medical
Sciences, New Delhi, Delhi, India
ADC were measured at whole tumor (WT), and from five
geographical zones from inside tumor margin (IM) in a
layerwise manner to outside tumor margin III (OM1, OM2,
OM3) and intra-tumoral necrotic domains (Nec)
sequentially i.e., prior to (Tp0), after I (Tp1) and III
(Tp3) neoadjuvant chemotherapy (NACT) in 36 breast
cancer patients. A significant increase in ADC was seen
for WT and IM, while it decreased at OM1 compared to OM2
and OM3 at Tp3. The change in ADC of WT and nec after
therapy showed positive Pearson correlation. Results
indicated the utility of DWI in breast conservation
surgery.
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