Abstract #3922
Method for epileptogenic focus localization using BOLD signal complexity analysis
Vnia Tavares 1 , Andr Santos Ribeiro 1,2 , Carlos Capela 3 , Lus Cerqueira 4 , and Hugo Alexandre Ferreira 1
1
Institute of Biophysics and Biomedical
Engineering, Faculy of Sciences of the University of
Lisbon, Lisboa, Portugal,
2
Centre
for Neuropsychopharmacology, Division of Brain Sciences,
Department of Medicine, Imperial College London, London,
United Kingdom,
3
Department
of Neurology, Centro Hospitalar Lisboa Central, Lisbon,
Portugal,
4
Department
of Neuroradiology, Centro Hospitalar Lisboa Central,
Lisbon, Portugal
A method for localizing the epileptogenic focus from
functional magnetic resonance imaging data was
developed. For that purpose a bi-dimensional temporal
clustering analysis was used to identify potential
epileptogenic foci. Then, the complexity of the
corresponding BOLD signals was analyzed to identify the
most probable focus. Complexity analysis comprised the
use of a modified multiscale entropy analysis algorithm
and the detrended fluctuation analysis algorithm.
Results showed that this method is able to localize
epileptogenic tissue in agreement with clinical
knowledge. Results also showed that the epileptogenic
foci influence the dynamics of related brain regions
within epileptic networks.
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