Abstract #3924
Sodium fMRI detects grey and white matter activations: neuronal firing or blood volume change?
Frank Riemer 1,2 , Bhavana S. Solanky 1 , Xavier Golay 2 , Egidio U. D'Angelo 3 , and Claudia A. M. Wheeler-Kingshott 1
1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, Institute of
Neurology, University College London, London, United
Kingdom,
2
Department of Brain Repair and
Rehabilitation, Queen Square MS Centre, Institute of
Neurology, University College London, London, United
Kingdom,
3
Brain
Connectivity Center, C. Mondino National Neurological
Institute, Pavia, Italy
Sodium (23Na) fMRI is a novel approach to study brain
function. Its physiological underpinning may come from
the temporal increase in intracellular sodium during
neuronal firing, but also from an increase in blood
volume. During finger-tapping, contralateral motor,
premotor and ipsilateral somatosensory, insula and
cerebellum grey matter areas are activated.
Interestingly, 23Na-fMRI reveals unique activations in
grey matter/white matter bordering regions where we
expect the highest presence of sodium channels and in
areas of associative white matter fibers such as the
superior longitudinal fasciculus and the inferior
cerebellar peduncle, supporting the hypothesis that
23Na-fMRI is sensitive to intracellular sodium
accumulation.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
