Abstract #3935
Separating the magnitude and temporal responses in a BOLD-based CO2 hypercapnia leads to improved inter-session reliability as well as characterization of hemodynamic impairment: a clinical multi-cohort study
David E Crane 1 , Anoop Ganda 1 , David J Mikulis 2 , Sandra E Black 1 , and Bradley J MacIntosh 1
1
Sunnybrook Research Institute, Toronto, ON,
Canada,
2
Toronto
Western Hospital, Toronto, ON, Canada
Hypercapnia-induced cerebrovascular reactivity is a
powerful tool to study the ability of the brains blood
vessels to vasodilate. The clinical utility of CVR has
been demonstrated in multiple applications. There are
however continued efforts to improve the CVR time-series
analysis. In this study we introduce a deconvolution
approach that produces a vascular transfer function,
which can be calculated by tissue type or at a
voxel-wise level. We found this approach had higher
sensitivity to patient group differences in white
matter, compared to conventional CVR, and therefore may
be useful as an adjunct approach.
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