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Abstract #3952

Observing the activity change of the baseline brain in Benign Essential Blepharospasm with fractional amplitude of low-frequency fluctuation

Mingfei Ni 1 , Weiwei Wang 1 , Ziheng Zhang 2 , Qingwei Song 1 , Ailian Liu 1 , and Yanwei Miao 1

1 Radiology Department, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China, 2 GE Healthcare China, Beijing, China

Objective:To investigate the activity changes of the baseline brain in patients with Benign Essential Blepharospasm (BEB) by resting-state fMRI fractional amplitude of low-frequency fluctuation (fALFF) method.Methods:28 patients with BEB and 28 healthy controls group were scanned on a 3.0T MRIscanner. The image data were analyzed with software SPM8, DPARSF and REST. Results The whole brain analysis indicated that in comparison with the normal control group, there was a ncreased fALFF in the right major sensorimotor arearight caudate headleft thalamus. the fALFF in the left thalamus were positively correlated with the JRS total score.

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