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Abstract #3954

Functional connectivity MRI can distinguish experimental pain from the resting state with seed ROI in the posterior insula, but not the anterior insula

Keith M Vogt 1 and James W Ibinson 2

1 Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States, 2 Center for Pain Research, Dept of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, United States

The portion of the insula chosen as the seed region for functional connectivity MRI (fcMRI) analysis can dramatically affect the resulting maps. This is particularly important when comparing maps obtained during rest to those during experimental pain. In this fcMRI study, seed region analyses revealed that the difference maps for posterior insula Pain vs Rest connectivity was obviously different than those seen with an anterior insular seed region. Thus, the posterior insula is a putative brain area for differentiating the experience of acute pain from rest, while the anterior insula does not exhibit this specificity.

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