What can multiple b-value 3 He MRI tell us about lung micro-structure in healthy elderly never-smokers?
Gregory Paulin 1,2 , Alexei Ouriadov 1,2 , Khadija Sheikh 1,2 , David G McCormack 3 , and Grace Parraga 1,2
Imaging Research Laboratories, Robarts
Research Institute, London, Ontario, Canada,
of Medical Biophysics, The University of Western
Ontario, London, Ontario, Canada,
of Respirology, Department of Medicine, The University
of Western Ontario, London, Ontario, Canada
Diffusion-weighted noble gas pulmonary MRI provides in
vivo images with contrast uniquely sensitive to
molecular displacement at cellular and sub-cellular
length scales. We estimated the external airway radius
and internal airway radius of alveoli to evaluate
potential differences in acinar duct morphometries in
healthy older never-smokers using a multi-slice 2D
gradient echo diffusion-weighted sequence. Preliminary
results show that MRI measurements of lung morphometry
in older never-smokers were elevated compared to
previous results reported in younger never-smokers.
These findings are compatible with senile emphysematous
changes to healthy lung parenchyma that accompanies
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