Parallel Imaging for Short Breath Hold Times in Perfluorinated Gas Imaging of the Lung
Hal Cecil Charles 1 , Randall W. Jones 2 , Ahmed F. Halaweish 3 , and Maureen D. Ainslie 1
Radiology, Duke Image Analysis Laboratory,
Duke University Medical School, Durham, NC, United
Omaha, Nebraska, United States,
Siemens Healthcare, MN, United States
Airway diseases (e.g. COPD and asthma) represent an
economic burden in the US of approximately $100 billion
annually and up to $90 billion annually, respectively.
In order to fully understand lung function in airway
disease a major challenge lies in the regional
determination of poorly ventilated compartments in the
lung. We have developed a method of imaging gas wash-in
and wash-out that gives us a quantitative measure of
mechanical ventilation the rate of gas replacement
normalized to gas volume. We have implemented parallel
imaging of perfluorinated gas/oxygen mixtures to shorten
breath hold times in subjects with severe lung disease.
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