Abstract #4023
MRI- R2* Relaxometry for assessment of kidney iron accumulation as a cause of renal dysfunction in patients with sickle cell disease (SCD)
Sarah Keller 1 , Bjoern Schoennagel 1 , Zhiyue Jerry Wang 2 , Regine Grosse 3 , Peter Nielsen 4 , Gerhard Adam 1 , Roland Fischer 1 , and Jin Yamamura 1
1
Diagnostic and Interventional Radiology,
University Medicine Hamburg Eppendorf, Hamburg, Germany,
2
Radiology,
Children's Medical Center Dallas, Dallas, Texas, United
States,
3
Pediatric
Hematology and Oncology, University Medicine Hamburg
Eppendorf, Hamburg, Germany,
4
Institute
of Biochemistry and Molecular Biology, Center of
Experimental Medicine, Hamburg, Germany
Renal iron accumulation leading to renal dysfunction and
impairment may be an underestimated factor during
disease course of transfusion dependent haematological
diseases like Hereditary Hemochromatosis (HHC), Sickle
Cell Disease (SCD) and Transfusion dependent Thalasemia
(TDT). R2* -MRI and biomagnetic liver susceptometry
(SQUID-BLS) was applied to estimate cortical and
medullary renal and liver iron content. Correlation
analysis of iron accumulation and laboratory findings
(lactate dehydrogenase, bilirubin) was performed to
estimate organ involvement.
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