Early Changes in Renal Hypoxia Following Iodinated Contrast: Need for Real-time Monitoring
Lu-Ping Li 1,2 , Jing Lu 2,3 , Tammy Franklin 1 , Ying Zhou 4 , Richard Solomon 5 , and Pottumarthi V. Prasad 1,2
Department of Radiology / Center for
Advanced Imaging, Northshore University Healthsystem,
Evanston, IL, United States,
School of Medicine, University of Chicago, Chicago, IL,
of Obstetrics and Gynecology, Northshore University
Healthsystem, Evanston, IL, United States,
for Clinical & Research Informatics, Northshore
University Healthsystem, Evanston, IL, United States,
University of Vermont, VT, United States
The current clinical marker (serum creatinine) is not
time-sensitive to guide intervention to prevent
iodinated contrast induced acute kidney injury (CIAKI).
Blood-oxygenation-level dependent (BOLD) MRI showed near
real time changes in renal hypoxia following contrast
administration in a previous functional CIAKI rat model.
In this study, streptozotocin induced diabetic rat was
used as a CIAKI susceptible model. While the renal
hypoxia in medulla increased following contrast
administration, it fell back towards baseline. Urinary
NGAL increasing confirmed AKI. This indicates the need
for real time marker to monitor the temporal changes of
renal hypoxia during contrast administration.
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