MR-GUIDED HIGH INTENSITY FOCUSED ULTRASOUND FOR ABLATED KIDNEY: MR PERFUSION ASSESSMENT AND MICROSCOPIC CHARACTERIZATION
Maythem Saeed 1 , Loi Do 1 , Mark W Wilson 1 , and Roland Krug 1
Radiology and Biomedical Imaging, University
of California San Francisco, San Francisco, Ca, United
This swine study aimed to demonstrate the perfusion
deficits, as an early indicator, of successful thermal
MRg-HIFU ablation. Kidneys (n=12) were ablated after
minimizing diaphragm motion using rocuronium injection
and breath-hold. Saturation recovery-GRE was used after
ablation to monitor regional perfusion in ablated,
viable and aortic blood to obtain perfusion data. This
study shows the potential of perfusion imaging as an
early indicator of successful ablation. Thermal MRg-HIFU
causes loss of vascular and cellular integrity. The
severity of injury is dependent on the energy used.
Thus, the used energy must be optimized in the kidney
for future translation to clinic.
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