Proton density fat fraction and liver water and fat T2 as measured by multi-TR, multi-TE 1 H MRS compared to multi-TE 1 H MRS.
Gavin Hamilton 1 , Michael S Middleton 1 , Alexandra N Schlein 1 , Catherine A Hooker 1 , Lisa Clark 1 , Rohit Loomba 2 , and Claude B Sirlin 1
Department of Radiology, UC San Diego, San
Diego, California, United States,
of Medicine, UC San Diego, San Diego, California, United
We developed a rapid multi-TR, multi-TE
MRS sequence for
fat quantification and characterization that acquires 32
single-average spectra in a single breath-hold. Here we
compare the estimates of water and fat T2 and proton
density fat fraction (PDFF) given by the multi-TR,
multi-TE sequence with those given by the current MRS
standard: a long-TR, multi-TE sequence. We find good
agreement between the sequence estimates of PDFF and
water T2. However there is little agreement for fat T2.
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