MRI-R2* Relaxometry for cardiac, pancreatic and hepatic iron assessment in patients with Hereditary Hemochromatosis
Sarah Keller 1 , Bjoern Schoennagel 1 , Zhiyue Jerry Wang 2 , Regine Grosse 3 , Peter Nielsen 4 , Gerhard Adam 1 , Roland Fischer 1 , and Jin Yamamura 1
Diagnostic and Interventional Radiology,
University Medicine Hamburg Eppendorf, Hamburg, Germany,
Children's Medical Center Dallas, Dallas, Texas, United
Hematology and Oncology, University Medicine Hamburg
Eppendorf, Hamburg, Germany,
of Biochemistry and Molecular Biology, Center of
Experimental Medicine, Hamburg, Germany
Hereditary hemochromatosis (HH) is frequently associated
with cardiomyopathy and iron accumulation in the heart
beyond increased hepatic iron concentration (HIC).
Measurements of cardiac and hepatic iron concentration
in patients with HH are rare (Olson et al, 1987) and
sporadic cases seem to be reported less frequently.
MRI-R2* Relaxometry combined with Biosusceptometry was
performed to assess cardiac, hepatic and pancreatic iron
accumulation and relative fat/water content in 7
homozygotes with HH (C282Y: n=4, H63D: n=3).
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