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Abstract #4086

Investigation of 3D Lava-flex in fat fraction estimation for patients with hepatic iron-overloading

Tianyong Xu 1 , Qian Jiang 1 , Bing Wu 1 , Kai Xu 2 , and Zhenyu Zhou 1

1 GE Healthcare China, Beijing, Beijing, China, 2 The Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu, China

Knowledge of fat content in liver is not only useful for hepatic disease diagnosis but also valuable in monitoring recovery and assessing treatment effectiveness. Dual echo 2D SPGR is a routinely used sequence for obtaining the quantitative fat fraction by deriving the signal intensity ratios of in-phase and out-of-phase images. However it may fail for patients with liver iron-overloading that leads to shortened T2*, and the in-phase images suffer from low SNR that affects the accuracy of calculation. We investigate if the LAVA-flex sequence may be an iron overloading immune method for fat fraction assessment in patients diagnosed with hematopathy.

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