Prospective Radiology-Pathology Correlation of DCE-MRI Derived Parameters as Quantitative Biomarker of Vascularity and Fibrosis in Pancreatic Cancer
Michael Z Liu 1 , Sachin Jambawalikar 1 , Helen R Remotti 1 , Stuart W Weisberg 1 , Pascal Spincemaille 2 , Henry Rusinek 3 , Artem V Mikheev 3 , Martin Prince 1 , Donald Garmon 1 , Yanghee Woo 1 , John Chabot 1 , and Elizabeth M Hecht 1
Columbia University, New York, NY, United
University, New York, United States,
York University, New York, United States
In this study, we assess the agreement between
quantitative imaging parameters derived from dynamic
contrast enhanced (DCE) MRI and mean vascular density
and percent fibrosis in 15 participants with pancreatic
cancer.Spiral k-space 3D T1w GRE was used quantitatively
in DCE-MRI permitting whole liver/pancreas coverage with
sub 3 second temporal resolution. Ve and kep may serve
as biomarkers of fibrosis and MVD while Ktrans does not.
This may be due to the characteristic high desmoplasia
and relatively low perfusion of pancreatic
adenocarcinomas. Higher temporal resolution can be
extracted from this data and alternative kinetic
modeling may further bring out the unique features of
pancreatic adenocarcinoma. Preliminary results in humans
comparing DCE metrics with Gadofosveset trisodium to
extracellular agents are presented.
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