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Abstract #4108

Prospective Radiology-Pathology Correlation of DCE-MRI Derived Parameters as Quantitative Biomarker of Vascularity and Fibrosis in Pancreatic Cancer

Michael Z Liu 1 , Sachin Jambawalikar 1 , Helen R Remotti 1 , Stuart W Weisberg 1 , Pascal Spincemaille 2 , Henry Rusinek 3 , Artem V Mikheev 3 , Martin Prince 1 , Donald Garmon 1 , Yanghee Woo 1 , John Chabot 1 , and Elizabeth M Hecht 1

1 Columbia University, New York, NY, United States, 2 Cornell University, New York, United States, 3 New York University, New York, United States

In this study, we assess the agreement between quantitative imaging parameters derived from dynamic contrast enhanced (DCE) MRI and mean vascular density and percent fibrosis in 15 participants with pancreatic cancer.Spiral k-space 3D T1w GRE was used quantitatively in DCE-MRI permitting whole liver/pancreas coverage with sub 3 second temporal resolution. Ve and kep may serve as biomarkers of fibrosis and MVD while Ktrans does not. This may be due to the characteristic high desmoplasia and relatively low perfusion of pancreatic adenocarcinomas. Higher temporal resolution can be extracted from this data and alternative kinetic modeling may further bring out the unique features of pancreatic adenocarcinoma. Preliminary results in humans comparing DCE metrics with Gadofosveset trisodium to extracellular agents are presented.

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