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Abstract #4117

Bone marrow fat behaves differently from abdominal fat, liver fat and serum lipids after a four-week calorie restriction in obese women

Christian Cordes 1 , Michael Dieckmeyer 1 , Beate Ott 2 , Jun Shen 1 , Stefan Ruschke 1 , Marcus Settles 1 , Claudia Eichhorn 2 , Jan S. Bauer 1 , Hendrik Kooijman 3 , Ernst J. Rummeny 1 , Thomas Skurk 2 , Thomas Baum 1 , Hans Hauner 2 , and Dimitrios C. Karampinos 1

1 Diagnostic and Interventional Radiology, Technische Universitt Mnchen, Mnchen, Germany, 2 Else Krner Fresenius Center for Nutritional Medicine, Technische Universitt Mnchen, Mnchen, Germany, 3 Phillips Healthcare, Hamburg, Germany

Bone marrow is a fat depot that has recently attracted a considerable research interest due to its unique connections to metabolism and bone health. The present study examines the relationship between changes in bone marrow fat fraction (BMFF), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), liver fat and serum lipid levels after a four-week calorie restriction in twenty obese women. BMFF is shown to have smaller changes after the dietary intervention compared to SAT, VAT, liver fat and serum lipids. BMFF changes are also shown to be dependent on the abdominal tissue distribution before the dietary intervention.

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