Diffusion-weighted magnetic resonance imaging for the prediction of response to neoadjuvant chemoradiotherapy in esophageal cancer.
Peter S.N. van Rossum 1,2 , Astrid L.H.M.W. van Lier 1 , Marco van Vulpen 1 , Onne Reerink 1 , Steven H. Lin 3 , Richard van Hillegersberg 2 , Jelle P. Ruurda 2 , Gert J. Meijer 1 , and Irene M. Lips 1
Department of Radiotherapy, University
Medical Center Utrecht, Utrecht, Netherlands,
of Surgery, University Medical Center Utrecht, Utrecht,
of Radiation Oncology, The University of Texas MD
Anderson Cancer Center, Houston, Texas, United States
This study aimed to explore the value of
diffusion-weighted magnetic resonance imaging (DW-MRI)
for the prediction of response to neoadjuvant
chemoradiotherapy (nCRT) in esophageal cancer. In 20
patients receiving nCRT for esophageal cancer DW-MRI
scanning was performed before nCRT, after 8-13
fractions, and before surgery. The median tumor apparent
diffusion coefficient (ADC) was determined at these
three time points. The predictive potential of initial
tumor ADC, and change in ADC (ΔADC) during and after
treatment for pathologic complete response (pathCR) was
assessed. The treatment-induced change in ADC during the
first 2-3 weeks of nCRT (ΔADCduring) was highly
predictive for pathCR.
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