Meeting Banner
Abstract #4148

Multinuclear ( 19 F + 1 H) MRI at 3T using an internal probe

Shashank Sathyanarayana Hegde 1 , Li Pan 2 , Guan Wang 1,3 , Martin Radvany 1 , Yingli Fu 1 , and Dara L Kraitchman 1

1 Radiology, Johns Hopkins University, Baltimore, Maryland, United States, 2 Siemens Healthcare, Baltimore, Maryland, United States, 3 Electrical and Computer Engineering, Johns Hopkins University, Maryland, United States

We developed and characterized an internal probe at 3T designed for interchangeable 1 H and 19 F use. The internal probe demonstrated increased signal-to-noise ratio with respect to a conventional 19 F surface coil for structures deeper than 2 cm from the surface. 19 F imaging of ~7.5mL of a 10-fold dilution (e.g., 5 mg/ml) of fluorouracil (5-FU) was possible in 2 minutes. Multinuclear MRI of perfluorooctyl bromide (PFOB) microcapsules was performed in tissue samples ex vivo and a rabbit thigh in vivo. High-resolution (0.2 mm 1 H and 0.8 mm 19 F in-plane) MRI of PFOB capsules was possible and was concordant with cone beam computed tomography (CT) imaging of the radiopaque microcapsules.

This abstract and the presentation materials are available to members only; a login is required.

Join Here