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Abstract #4165

Investigation of In-vivo Relationship between Cartilage Contact and Cartilage Quantitative MR Parameters

Fang Liu 1 , Jarred Kaiser 2 , Walter F. Block 1,3 , Darryl G. Thelen 2,3 , and Richard Kijowski 4

1 Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, United States, 2 Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, United States, 3 Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, United States, 4 Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, United States

A novel dynamic and static MR method was proposed to investigate the in-vivo relationship between cartilage contact and quantitative cartilage MR parameters in an asymptomatic subject following anterior cruciate ligament reconstruction surgery. A cartilage contact map of the tibia plateau was created using dynamic SPGR-VIPR imaging performed during active loaded knee flexion and extension, cartilage thickness map was created using 3D fast spin-echo imaging, and cartilage single-component T2 and fast relaxing water fraction (Ff) maps were created using mcDESPOT imaging. Cartilage contact was found to positively correlate with cartilage thickness and cartilage Ff and negatively correlate with cartilage T2.

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