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Abstract #4182

Cluster Analysis for T 2 and T 1rho Relaxation Times using 3D Projection Maps of the Femoral Condyle in a Healthy and ACL-injured Population

Uchechukwuka Diana Monu 1,2 , Brian A Hargreaves 1,2 , Caroline D Jordan 2,3 , Garry E Gold 2,3 , and Emily J McWalter 2

1 Electrical Engineering, Stanford University, Stanford, California, United States, 2 Radiology, Stanford University, Stanford, California, United States, 3 Bioegineering, Stanford University, Stanford, California, United States

Osteoarthritis (OA) is a heterogeneous and multifactorial joint disease that is characterized by morphological, biochemical and structural changes to the cartilage. The etiology and progression of the disease remains largely uncertain making disease modifying treatments challenging. This works uses parametric MRI modeling and a 3D visualization technique to track clusters of elevated T2 and T1rho relaxation times in an ACL-injured population. Results show the potential for cluster analysis to identify and quantify focal defects in cartilage over time. This may provide a useful biomarker for tracking early cartilage degeneration.

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