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Abstract #4197

Combined microCT-microMR imaging in the tridimensional evaluation of bone regeneration

Allegra Conti 1 , Raffaele Sinibaldi 1 , Sara Spadone 1 , Tonino Traini 2 , Giuliana Tromba 3 , Silvia Capuani 4 , Gian Luca Romani 1,5 , and Stefania Della Penna 1,5

1 Department of Neuroscience, Imaging and Clinical Sciences, G. D'Annunzio Univ. of Chieti and Pescara, Chieti, CH, Italy, 2 Department of Stomatology and Biotechnologies, G. D'Annunzio Univ. of Chieti and Pescara, Chieti, CH, Italy, 3 Elettra-Sincrotrone Trieste S.C.p.A., Basovizza, TS, Italy, 4 Physics Department, 'La Sapienza' University of Rome, Roma, RM, Italy, 5 Institute for Advanced Biomedical Technologies (ITAB), G. D'Annunzio Univ. of Chieti and Pescara, Chieti, CH, Italy

We present here a 3D analysis of extracted human jawbone cores following restoration of bone mass. First, X-ray Synchtron-Radiation-micro-CT and micro-MR images were co-registered using a new in-house software. Then, a clusterization algorithm was applied to generate a 3D meta-structure of the sample, producing six clusters. Histology made on sample slabs was used to label the clusters as mature bone, two types of newly formed bone, soft tissue, multinucleate cells and empty spaces. Notably, the presence of two different phases of newly formed bone was not revealed by lower case Greek mu MRI and SR lower case Greek mu CT when used as separate imaging tools.

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