Combined microCT-microMR imaging in the tridimensional evaluation of bone regeneration
Allegra Conti 1 , Raffaele Sinibaldi 1 , Sara Spadone 1 , Tonino Traini 2 , Giuliana Tromba 3 , Silvia Capuani 4 , Gian Luca Romani 1,5 , and Stefania Della Penna 1,5
Department of Neuroscience, Imaging and
Clinical Sciences, G. D'Annunzio Univ. of Chieti and
Pescara, Chieti, CH, Italy,
of Stomatology and Biotechnologies, G. D'Annunzio Univ.
of Chieti and Pescara, Chieti, CH, Italy,
Trieste S.C.p.A., Basovizza, TS, Italy,
Department, 'La Sapienza' University of Rome, Roma, RM,
for Advanced Biomedical Technologies (ITAB), G.
D'Annunzio Univ. of Chieti and Pescara, Chieti, CH,
We present here a 3D analysis of extracted human jawbone
cores following restoration of bone mass. First, X-ray
Synchtron-Radiation-micro-CT and micro-MR images were
co-registered using a new in-house software. Then, a
clusterization algorithm was applied to generate a 3D
meta-structure of the sample, producing six clusters.
Histology made on sample slabs was used to label the
clusters as mature bone, two types of newly formed bone,
soft tissue, multinucleate cells and empty spaces.
Notably, the presence of two different phases of newly
formed bone was not revealed by
when used as separate imaging tools.
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