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Abstract #4208

Characterization of [ 18 F]-FDG uptake by hybrid PET-MRI in osteoarthritis of the hip

Audrey P. Fan 1 , Feliks Kogan 1 , Dawn Holley 1 , Andrei Iagaru 1 , Greg Zaharchuk 1 , and Garry E. Gold 1

1 Radiology, Stanford University, Stanford, CA, United States

[ 18F ]-FDG tracer uptake is a potential PET marker of musculoskeletal inflammation, but its biodistribution in osteoarthritis (OA) and colocalization with morphological changes are not well studied. We characterized [ 18F ]-FDG tracer uptake within different areas of OA joint damage in the hip identified on simultaneously acquired structural MRI scans. Twenty patients (mean age = 67 years) were scanned on a 3T hybrid PET-MR system with time-of-flight PET and with T2 STIR (short TI inversion recovery) MRI. An experienced radiologist identified 7 subchondral cysts and 10 areas of bone marrow lesions (BMLs) on the MR images. Mean standard uptake value (SUV mean ) was highest in joint fluid, which may reflect increased tracer diffusion or high glucose metabolism due to inflammation. SUV mean was also elevated in subchondral cysts and BMLs relative to SUV in normal regions of the femoral head. Our observations enable improved understanding of [ 18 F]-FDG uptake in normal and diseased joint tissue.

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