Diffusion-Weighted,Triple-Fat-Suppressed Echo-Planar Imaging Provides 'Anomalous' Diffusion Metrics for Assessment of Muscle Quality in the Human Thigh
Donnie Cameron 1 , Mustapha Bouhrara 1 , David A. Reiter 1 , Kenneth W. Fishbein 1 , Christopher M. Bergeron 1 , and Richard G. Spencer 1
National Institute on Aging, National
Institutes of Health, Baltimore, Maryland, United States
In diffusion-weighted imaging (DWI) of the thigh,
anomalous diffusion models may better reflect muscle
architecture than conventional Gaussian models. In this
work, four models were investigatedmonoexponential,
intravoxel incoherent motion, diffusional kurtosis, and
stretched exponentialand a triple-fat-suppressed
sequence was developed to mitigate fat contributions.
Eight volunteers were scanned at 3T, with sixteen
b-values applied in the slice and read directions, and
diffusion parameter maps were generated. In the read
direction, kurtosis and the stretching parameter were
non-Gaussian (>0 and <1), and the stretched exponential
fit the data bestsuggesting some merit for non-Gaussian
models in assessment of muscle quality.
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