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Abstract #4250

Advanced pathology in aged mdx muscle characterized by quantitative multi-parametric MRI

Nathan David Bryant 1,2 , Ke Li 1,2 , and Bruce Damon 1,2

1 Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 2 Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

Dystrophic skeletal muscles, from mdx mice of advanced age and stages of myopathy, were characterized using an array of quantitative metrics derived from a multi-parametric MRI approach including: T2, DTI and qMT-MRI data that were collected in a single imaging session. These observations were compared to age matched healthy control mice. Compared to healthy control muscle, old mdx gastroc muscles were observed to have in increased T2, but were not different in terms of the diffusion indices investigated. However, the qMT parameters R1f, PSR, and kmf were all decreased in the histologically-verified fibrotic and advanced dystrophic pathology mdx muscle.

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