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Abstract #4256

Correlation between quantitative MRI features and functional assessment of myopathy

Hon J. Yu 1,2 , Manaswitha Khare 3 , Mathew Gargus 3 , Marie Wencel 3 , Abhilasha Surampalli 3 , Vince Caiozzo 4 , and Virginia Kimonis 3

1 Radiological Sciences, University of California, Irvine, CA, United States, 2 Tu & Yuen Center for Functional Onco-Imaging, University of California, Irvine, CA, United States, 3 Pediatrics, University of California, Irvine, CA, United States, 4 Orthopaedic Surgery, University of California, Irvine, CA, United States

MRI and biophysical evaluation were performed on eight subjects consisting of control and patients with varying degrees of myopathy. Despite small sample size, the potential for quantitative MRI features based on texture analysis is demonstrated as a functional means for muscle function in comparison with dynamometer-based muscle strength measurements, which could be an invaluable tool in study of the disease progression and/or treatment intervention in both clinical and research setting.

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