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Abstract #4279

Altered Spontaneous Brain Activity in Type 2 Diabetes Related Cognitive Dysfunction: a Resting-State Functional MRI Study

Ying Xiong 1 , Zhipeng Xu 2 , Qiang Zhang 3 , Shiqi Yang 1 , Shun Zhang 1 , and Wenzhen Zhu 1

1 Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, 2 Pathophysiology Department, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, 3 Neurology department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

This study aims to investigate the possible alterations in spontaneous neural activity through resting-state functional MRI (rs-fMRI) in type 2 diabetes mellitus (T2DM) related cognitive impairment. Thirty-four T2DM patients were divided into two groups based on their cognition status. The intrinsic and spontaneous neural activity, represented by the regional homogeneity (ReHo), was detected to decrease in right temporal regions and to increase in bilateral frontal regions. Weaker connectivities of multiple brain regions were also revealed in the cognitive impairment group. These multi-functional brain disorders revealed by rs-fMRI may help to discover the susceptible regions to T2DM induced cognitive dysfunction.

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