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Abstract #4284

Transverse Relaxation and Volumetric Neural Changes in the H67D HFE Mouse Model and Cognitively Normal Healthy H63D-HFE Human Genotype Carriers

Douglas G Peters 1,2 , Carson J Purnell 1 , Jian-Li Wang 3 , Paul J Eslinger 4 , Megha Vasavada 3 , Fatima Ali-Rahmani 1 , Qing X Yang 3 , James R Connor 1 , and Mark David Meadowcroft 1,3

1 Neurosurgery, The Pennsylvania State University - College of Medicine, Hershey, Pennsylvania, United States, 2 Neural and Behavioral Sciences, The Pennsylvania State University - College of Medicine, Hershey, Pennsylvania, United States, 3 Radiology, The Pennsylvania State University - College of Medicine, Hershey, Pennsylvania, United States, 4 Neurology, The Pennsylvania State University - College of Medicine, Hershey, Pennsylvania, United States

A voxel-based statistical parametric analysis of R 2 transverse relaxation in cognitively normal H63D-HFE human and H67D knock-in mice compared to control patients and mice was accomplished. Widespread decreases in relaxation were found in white association fibers throughout the brain of H63D patients and in white matter tracks of the H67D mice. The R 2 changes observed in both the human-H63D and mouse-H67D data suggest that the sequential process of myelinogenesis is refashioned, resulting in modified myelin membrane proton compartmentalization in patients with HFE mutations.

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