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Abstract #4288

An MRI-based method to quantify apoptosis in vivo

Chenchen Liu 1 , Nuri B Farber 2 , Joel R Garbow 3 , and Joseph JH Ackerman 4

1 Chemistry, Washington University in St.Louis, St. Louis, MO, United States, 2 Psychiatry, Washington University in St.Louis, St. Louis, MO, United States, 3 Radiology, Washington University in St.Louis, St. Louis, MO, United States, 4 Chemistry and Radiology, Washington University in St.Louis, St. Louis, MO, United States

Apoptosis is a cell-eliminating process in which unhealthy/unneeded cells are culled in a controlled manner. Currently, histology is the gold-standard method for qualifying/quantifying apoptosis. However, histological techniques require resection and destruction of the tissue, thus longitudinal pre-clinical and clinical studies are infeasible. MRI may offer a non-invasive/non-destructive and translatable means to detect and quantify apoptosis. We have initiated such studies by taking advantage of the high sensitivity afforded by pre-clinical MRI at 11.74 T with a rodent ethanol-induced apoptosis model. We observed a 23% signal enhancement in apoptotic cingulate cortex with T1-weighted imaging 4h after ethanol injection.

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