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Abstract #4294

MRI patterns of atrophy associated with Parkinsons subtypes

Yue Xing 1 , Stefan Schwarz 1 , Nin Bajaj 2 , Penny Gowland 3 , and Dorothee Auer 1

1 Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom, 2 Division of Neurology, Nottingham University Hospitals NHS Trust, Nottingham, Nottinghamshire, United Kingdom, 3 Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom

To assess whether gray matter (GM) atrophy between 2 Parkinson disease (PD) subtypes: the tremor dominant (TD) subtype and the postural instability gait difficulty (PIGD), we used multivariate pattern classification analysis (MVPA) on cortical thickness in people with Parkinsons. Our result show MVPA is sensitive to discriminate the patterns of GM loss of these two subtypes, which suggest GM atrophy may provide useful information for classification different motor subgroup of PD.

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