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Abstract #4320

Correlation between cerebral glutathione, dietary intake and cognitive function in aging and Alzheimers disease

In-Young Choi 1,2 , Jeffrey M. Burns 3 , Debra K. Sullivan 4 , Hung-Wen Yeh 5 , William M. Brooks 1,2 , and Phil Lee 1,6

1 Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, 2 Neurology, University of Kansas Medical Center, Kansas City, KS, United States, 3 Neurology, University of Kansas Medical Center, Kansas City, Kansas, United States, 4 Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS, United States, 5 Biostatistics, University of Kansas Medical Center, Kansas City, KS, United States, 6 Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States

Increased generation of free radicals leads to oxidative damage and changes in antioxidant status and cognitive function. Thus, a reduction in glutathione (GSH), a major antioxidant, might be an early event in aging and neurodegeneration. In this study, we measured the relationship between cerebral GSH, nutrient intake and cognitive function in aging and AD using doubly-selective multiple quantum GSH CSI at 3T. The GSH levels were significantly lower in AD compared with age/sex-matched controls and young adults. We also found a positive correlation of GSH with dairy intake as well as cognitive function, suggesting the importance of an adequate antioxidant status.

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