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Abstract #4329

Imaging biomarker and pathophysiology of early memory impairment in multiple sclerosis: a pre-clinical study with diffusion-tensor imaging of hippocampal layers.

Thomas Tourdias 1,2 , Vincent Planche 1 , Bassem Hiba 3 , Aline Desmedt 1 , Gerard Raffard 3 , Aude Panatier 1 , Stphane Oliet 1 , and Vincent Dousset 1,2

1 INSERM U862 Neurocentre Magendie, University of Bordeaux, Bordeaux, France, 2 Department of Neuroradiology, Bordeaux University hospital, Bordeaux, France, 3 UMR CNRS 5536, University of Bordeaux, Bordeaux, France

Early memory impairment was demonstrated in experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis. High-resolution DTI showed a selective decrease of FA in the molecular layer (ML) of the dentate gyrus of the cognitively-impaired EAE-mice compared to controls. While there was diffuse hippocampal microglia activation, a selective dendritic loss and neuronal death in the ML of the dentate gyrus were the main correlate of the low FA in EAE-mice. Treatment with the microglia inhibitor minocycline protected against this neurodegenerative process and prevented memory impairment; the effect being measurable as an increase of FA in treated-mice compared to placebo.

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