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Abstract #4341

Phase contrast MRI differentiates between brain lesions in Neuromyelitis optica and Multiple sclerosis preliminary data from a 7T MRI study

Tim Sinnecker 1 , Sophie Hahndorf 1 , Katharina Mueller 1 , Petr Dusek 2,3 , Lutz Harms 4,5 , Sanjeev Chawla 6 , Thoralf Niendorf 7,8 , Ilya Kister 9 , Friedemann Paul 1,4 , Yulin Ge 6 , and Jens Wuerfel 1,2

1 NeuroCure Clinical Research Center, Charit- Universitaetsmedizin, Berlin, Berlin, Germany, 2 Institute of Neuroradiology, Universitaetsmedizin Goettingen, Niedersachsen, Germany, 3 1st Faculty of Medicine and General University Hospital in Prague, Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, Praha, Czech Republic, 4 Experimental and Clinical Multiple Sclerosis Research Center, Charit Universitaetsmedizin Berlin, Berlin, Germany, 5 Department of Neurology, Charit - Universitaetsmedizin Berlin, Berlin, Germany, 6 Department of Radiology, NYU School of Medicine, New York, NY, United States, 7 Berlin Ultrahigh Field Facility, Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 8 Max Delbrueck Center for Molecular Medicine, Experimental and Clinical Research Center, Charit - Universitaetsmedizin Berlin, Berlin, Germany, 9 Multiple Sclerosis Care Center, Department of Neurology, NYU School of Medicine, New York, NY, United States

Differentiating between seronegative Neuromyelitis optica (NMO) and multiple sclerosis (MS) with e.g. spinal predominance has remained challenging in clinical routine. Small supratentorial white matter lesions suggestive for MS may also be observed on conventional MRI in NMO. Here we studied the potential of highly resolving phase contrast MRI at 7 Tesla (T) that provides additional information on the tissue microstructure in differentiating NMO lesions from MS plaques. We observed unique morphological features of NMO and MS plaques. Hence, phase contrast MRI can be used to improve the distinction between NMO and MS brain lesions.

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